Polynucleotides cost UK: prices, sessions and what affects them (2026)

What are polynucleotides?

Polynucleotides are injectable regenerative treatments made from purified DNA fragments, usually salmon derived, designed to improve skin quality, hydration and elasticity rather than add volume. A 2025 systematic review in the Journal of Cosmetic Dermatology found polynucleotide injections showed promising outcomes in reducing wrinkles and improving skin texture and elasticity, with generally mild and transient side effects, while noting that larger, higher quality studies are still needed. In plain English: encouraging evidence, still maturing.

How much do polynucleotides cost in the UK?

Typical UK prices range from around £150 to £400 per session, with premium London clinics charging more. Most practitioners recommend a course of two to four sessions spaced a few weeks apart, so a realistic starting budget is £400 to £1,200, plus maintenance sessions once or twice a year.

What affects the price?

The area treated (under eyes is the most requested), the product used, the practitioner's experience and location, and whether the price includes review appointments. Always ask for the total course cost, not the per session headline.

Am I suitable?

Polynucleotides suit people whose main concern is skin quality: crepiness, dullness, tired looking under eyes, early laxity. They are typically derived from fish, so they are not suitable for people with fish allergies. If your goal is volume or dramatic change, a different conversation is more appropriate.

Is it safe?

Published reviews report side effects that are generally mild and short lived, such as small bumps, redness or bruising at injection points (review of current practices, 2024). As with any injectable, practitioner skill and product provenance matter more than anything else, so use the checks in our practitioner guide.

Quick answers

How much is one session of polynucleotides in the UK? Typically £150 to £400 depending on area, product and practitioner.

How many sessions of polynucleotides do I need? Most courses are two to four sessions, a few weeks apart, then maintenance.

How long do polynucleotide results last? Results build over weeks and typically require top ups every six to twelve months.

Find a vetted practitioner

Every practitioner on LumyIQ is vetted for qualifications and insurance. Start with a free scan to understand your skin first, then explore vetted practitioners offering polynucleotides near you.

These are cosmetic insights only, not medical advice. Always consult a qualified practitioner before any treatment. Prices are indicative and vary by practitioner.